New Efficient Nanostructural Near-IR Photosensitizer for Photodynamic Therapy of Malignancies based on Micellar Dispersion of Zinc octa-4,5-decylthio-octa-3,6-chlorophthalocyanine

The work is devoted to the investigation of new nanostructural photosensitizer based on phthalocyanine derivative – zinc octa-4,5-decylthio-octa-3,6-chlorophthalocyanine with absorption maximum at 730 nm. Active substance was solubilized in micellar form based on non-ionic Pluronic-like surfactant. Nanostructural properties of dispersions were studied by means of correlation laser spectrometry. Optimization of content and proportion of components allowed us to achieve high stability of nanostructural properties of dispersion stored at room temperature. Dynamics and selectivity of photosensitizer accumulation in tumor and normal tissue were estimated in vivo from absorption spectra of sensitized tissue measured by diffuse reflectance approach. Photosensitizer selectively accumulates in tumors. For PDT, they were irradiated using 732 nm laser with power density in a range of 100-300 mW/cm for 20 min. Tumor growth inhibition for Ehrlich tumor exceeded 80%.